The Basilica of San Simpliciano is a church in the centre of Milan, northern Italy, the second oldest in the form of a Latin cross, first erected by Saint Ambrose.
On the façade, the arcades that surmount the portals indicate the presence of an ancient portico, now disappeared. The upper part, the most modified in the 19th century, has two mullioned windows in the centre, an upper triple mullioned window and decorative arches. Late Renaissance mullioned windows also decorate the bell tower.

The interior is on the Latin cross plan, with a four-bay nave and two aisles. The transept is divided into two aisles.

The side chapels have decorations from various eras, from Renaissance to Baroque, Rococo and Neoclassical. In the right transept is a painting by Alessandro Varotari (Il Padovanino) portraying the Defeat of the Cammolesi. Next to the apse entrance are saints frescoed by Aurelio Luini. The apse vault is decorated by what is considered Ambrogio da Fossano's masterwork, a wide Incoronation of Mary.

Also on the left of the apse is the entrance to the small sacellum dedicated to the Martyrs of Anaunia, not before the end of the fourth century, as in a passage in Maximus of Turin's Sermo 81 Maximus designates himself a witness of the martyrdom of three missionary priests in 397 at Anaunia in the Rhaetian Alps.

The western wall of the transept has a Marriage of the Virgin by Camillo Procaccini.

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